DNA-PKcs 抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
DNA-PKcs 抗体

DNA-PKcs 抗体

商家询价

产品名称： DNA-PKcs 抗体

英文名称： DNA-PKcs Antibody

产品编号： XY19983-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 DNA-PKCS 抗体

Applications
In-house applications ELISA, WB     Application not tested? Please see our Guarantee.
Published applications WB Publications 3 citations –view here
Species specificity Human, Mouse; other species not tested.
Published Species Human
Images
Prev1NextView more validation data
  • 19983-1-AP;HeLa cellHeLa cells were subjected to SDS PAGE followed by western blot with 19983-1-AP(PRKDC antibody) at dilution of 1:300
Positive WB detected in HeLa cells, MCF7 cells
Recommended dilution WB : 1:500-1:5000
 DNA-PKCS 抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen Peptide Full name Protein kinase, DNA-activated, catalytic polypeptide
Calculated molecular
weight		 469 kDa Observed molecular 
weight		 350-460 kDa
GenBank accession 
number		 NM_006904 Gene ID (NCBI) 5591
Gene symbol PRKDC Synonyms DNA PK catalytic subunit, DNAPK, DNA-PKcs, DNPK1, HYRC, HYRC1, p350, p460, PRKDC, XRCC7
Background DNA-PKCS 抗体

PRKDC, also named as HYRC, HYRC1, DNPK1 and p460, belongs to the PI3/PI4-kinase family. PRKDC is a serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ), PRKDC is required for double-strand break (DSB) repair and V(D)J recombination. PRKDC must be bound to DNA to express its catalytic properties. It promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). It is required to protect and align broken ends of DNA. PRKDC may also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. It is found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. It also involved in modulation of transcription. It recognizes the substrate consensus sequence [ST]-Q. PRKDC phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. It phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, c-myc/MYC and RFA2. The antibody recognizes the C-term of PRKDC. DNA-PKCS 抗体

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