FITC标记的MAPK/ERK激酶3抗体
产品名称： FITC标记的MAPK/ERK激酶3抗体
英文名称： Anti-MEKK3/FITC
产品编号： HZ-18781R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-MEKK3/FITC Conjugated antibody
FITC标记的MAPK/ERK激酶3抗体
| 英文名称 | Anti-MEKK3/FITC |
| 中文名称 | FITC标记的MAPK/ERK激酶3抗体 |
| 别 名 | M3K3_HUMAN; MAP/ERK kinase kinase 3; MAP3K3; MAPK/ERK kinase kinase 3; MAPKKK3; MEK kinase 3; MEKK 3; MEKK3; mitogen activated protein kinase kinase kinase 3; Mitogen-activated protein kinase kinase kinase 3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 71kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MEKK3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] Function: Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 1 OPR domain. Contains 1 protein kinase domain. Database links: Entrez Gene: 4215 Human Entrez Gene: 26406 Mouse Entrez Gene: 303604 Rat Omim: 602539 Human SwissProt: Q99759 Human SwissProt: Q61084 Mouse Unigene: 29282 Human Unigene: 27041 Mouse Unigene: 72680 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因产物是与小鼠MEKK3相同的626氨基酸多肽。其催化结构域与其它几种激酶密切相关，包括小鼠MEKK2、烟草NPK和酵母STE11。Northern印迹分析显示4.6kb转录似乎无处不在表达。该蛋白通过分别激活SEK和MEK1/2直接调节应激激活蛋白激酶（SAPK）和细胞外信号调节蛋白激酶（ERK）通路，不调节p38通路。在共转染实验中，它增强核因子κB（NFKB）依赖性报告基因的转录，与SAPK途径的作用一致。另外，已经观察到编码不同亚型的剪接转录变体。[ RefSeq，JUL 2008 ]