TRPM3,瞬时受体电位离子通道蛋白3抗体

产品编号HZ-9046R
英文名称TRPM3
中文名称瞬时受体电位离子通道蛋白3抗体（M亚家族）
别 名GON 2; GON2; Long transient receptor potential channel 3; LTRPC 3; LTRPC3; Melastatin 2; Melastatin2; MLSN 2; MLSN2; Transient receptor potential cation channel subfamily M member 3; transient receptor potential cation channel, subfamily M, member 3; TRPM 3; TRPM3 protein.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 神经生物学 信号转导 通道蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
TRPM3,瞬时受体电位离子通道蛋白3抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量197kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human TRPM3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
TRPM3,瞬时受体电位离子通道蛋白3抗体PubMedPubMed
产品介绍background:
The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

Function:
Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. Expression in the brain and kidney was determined at protein level. In the kidney, expressed predominantly in the collecting tubular epithelium in the medulla, medullary rays, and periglomerular regions; in the brain, highest levels are found in the cerebellum, choroid plexus, the locus coeruleus, the posterior thalamus and the substantia nigra. Down-regulated in renal tumors compared to normal kidney.

TRPM3,瞬时受体电位离子通道蛋白3抗体Similarity:
Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM3 sub-subfamily.

Database links:
Entrez Gene: 476326 Dog
Entrez Gene: 80036 Human
Entrez Gene: 226025 Mouse
Entrez Gene: 309407 Rat
Omim: 608961 Human
SwissProt: Q9HCF6 Human
SwissProt: Q5F4S6 Mouse
Unigene: 47288 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.