RB1 polyclonal antibody
产品名称： RB1 polyclonal antibody
英文名称： RB1 polyclonal antibody
产品编号： PAB5554
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of RB1.
- Immunogen:
- A synthetic peptide corresponding to residues surrounding S807 of human RB1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Storage Buffer:
- In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Immunohistochemistry (1:50-1:100)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma.
Roesch A, Becker B, Meyer S, Hafner C, Wild PJ, Landthaler M, Vogt T.Mod Pathol. 2005 Apr;18(4):565-72.
- 2.
- MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation.
Chadee DN, Kyriakis JM.Nat Cell Biol. 2004 Aug;6(8):770-6. Epub 2004 Jul 18.
- 3.
- Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation.
Knudsen ES, Wang JY.Mol Cell Biol. 1997 Oct;17(10):5771-83.
- Entrez GeneID:
- 5925
- Gene Name:
- RB1
- Gene Alias:
- OSRC,RB,p105-Rb,pRb,pp110
- Gene Description:
- retinoblastoma 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq
- Other Designations:
- OTTHUMP00000018397,retinoblastoma suspectibility protein,retinoblastoma-associated protein
- Related Disease
- Adenocarcinoma
- Breast cancer
- Breast Neoplasms
- Carcinoma
- Carcinoma, Hepatocellular
- Carcinoma, Squamous Cell
- Chromosomal Instability
- Chromosome Aberrations
- Chromosome Deletion
- Colorectal Neoplasms
- Cystadenocarcinoma, Serous
- Disease Progression
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Head and Neck Neoplasms
- Liver Neoplasms
- Lung Neoplasms
- Lymphoma, Mantle-Cell
- Neoplasm Invasiveness