PeproTech重组人GASP-1 250ug-细胞/细菌培养-试剂-生物在线
美国PeproTech(派普泰克)公司中国代表处
PeproTech重组人GASP-1 250ug

PeproTech重组人GASP-1 250ug

商家询价

产品名称： PeproTech重组人GASP-1 250ug

英文名称： Recombinant Human GASP-1

产品编号： 120-41

产品价格： 0

产品产地： 美国

品牌商标： PeproTech

更新时间： null

使用范围： null

美国PeproTech(派普泰克)公司中国代表处
  • 联系人 :
  • 地址 :  江苏省苏州市工业园区星湖街218号A1北座4楼L03
  • 邮编 : 215123
  • 所在区域 : 江苏
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  • 邮箱 : peprotech.infochina@thermofisher.com
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Recombinant Human GASP-1
Catalog Number:
120-41
Synonyms:
GDF-associated serum protein-1, GASP, KIAA0443, WFIKKNRP
Description:
Growth and differentiation factor-associated serum protein-1 (GASP-1) is a secreted inhibitory TGF-β binding protein that contains multiple protease inhibitor structural domains. It is expressed primarily in the ovary, testis, and brain, and can act as a potent soluble inhibitor of myostatin and GDF-11, but not Activin-A. The GASP-1 gene encodes a 571 amino acid protein that contains a 29 amino acid secretion signal sequence, and multiple identifiable structural features, including a WAP domain, a follistatin/Kazal domain, an immunoglobulin domain, two tandem Kunitz domains, and a netrin domain. Recombinant human GASP-1 is a 542 amino acid protein that migrates at an apparent molecular weight of approximately 55-66 kDa by SDS-PAGE analysis under non-reducing conditions.
AA Sequence:
LPPIRYSHAG ICPNDMNPNL WVDAQSTCRR ECETDQECET YEKCCPNVCG TKSCVAARYM DVKGKKGPVG MPKEATCDHF MCLQQGSECD IWDGQPVCKC KDRCEKEPSF TCASDGLTYY NRCYMDAEAC SKGITLAVVT CRYHFTWPNT SPPPPETTMH PTTASPETPE LDMAAPALLN NPVHQSVTMG ETVSFLCDVV GRPRPEITWE KQLEDRENVV MRPNHVRGNV VVTNIAQLVI YNAQLQDAGI YTCTARNVAG VLRADFPLSV VRGHQAAATS ESSPNGTAFP AAECLKPPDS EDCGEEQTRW HFDAQANNCL TFTFGHCHRN LNHFETYEAC MLACMSGPLA ACSLPALQGP CKAYAPRWAY NSQTGQCQSF VYGGCEGNGN NFESREACEE SCPFPRGNQR CRACKPRQKL VTSFCRSDFV ILGRVSELTE EPDSGRALVT VDEVLKDEKM GLKFLGQEPL EVTLLHVDWA CPCPNVTVSE MPLIIMGEVD GGMAMLRPDS FVGASSARRV RKLREVMHKK TCDVLKEFLG LH
Source:
CHO cells
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to inhibit human Myostatin (GDF-8) activity in MCP-11 cells.  The ED50 for this effect is 0.0025-0.0040 µg/ml in the presence of 5ng/ml of human Myostatin (GDF-8).
 
 
 
 
Research Interests:
 
 
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.