Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. A member of the Krüppel C2H2-type zinc-finger protein family, ZNF274, also known as Zinc finger protein with KRAB and SCAN domains 19, is a 653 amino acid protein containing five C2H2-type zinc fingers, two KRAB A domains and one SCAN box domain. Predominantly localized to the nucleolus, ZNF274 exhibits transcriptional repressing activity. There are four isoforms of ZNF274 that are produced as a result of alternative splicing events. Although total ZNF274 expression seems to be ubiquitous, the two main isoforms, ZNF274a and ZNF274b, differ slightly in tissue distribution with higher expression of ZNF274a in testis and higher expression of ZNF274b in spleen, ovary, skeletal muscle and thymus.