Product: Anti-Cyclooxygenase-1 (COX-1), clone AS70
Cat. No: MC-453 (100 μg)
Background:
Cyclooxygenase (COX), also known as
prostaglandin H2 synthase and prostaglandin
endoperoxide synthase, is a key enzyme in the
conversion arachidonic acid to prostaglandin H2.
Prostaglandin H2 is converted by other enzymes
into inflammatory mediators prostaglandin (PG)
D2, PGE2, PGF2a, PGI2 and Thromboxane A2.
Thus, COX is a key enzyme in the production of
inflammatory agents and is the target of intense
research and drug discovery activities. There
are two enzymes of COX, COX-1 and COX-2.
COX-1 is constitutively produced in most cell
types. It is important in the gut for the
production of prostaglandins, which inhibit
gastric secretion. It can be induced in
monocytes, macrophages and other cells. It is
induced as part of the inflammatory response by
IL-1beta and other cytokines. It is induced by
growth factors such as EGF and PDGF.
Expression is inhibited by glucocorticosteroids
such as cortisol and dexamethasone.
Lipopolysaccharide in bacterial infections
induces COX-2. COX-2 is also found in
elevated levels in synoviocytes from rheumatoid
arthritis patients. The discomforts of
inflammation such as pain and swelling are
largely due to the action of prostaglandins
produced by COX-2.
Ig Isotype:
Mouse IgG1
Specificity:
Recognizes human COX-1
Format:
100 μg of purified antibody at 1 mg/mL in PBS
with 0.05% sodium azide.
Storage and Stability:
Antibodies should be stored at 4°C for short
periods. For longer storage aliquot and freeze
at -20°C.
Applications and Suggested Dilutions:

EIA
The optimal dilution for a specific application
should be determined by the researcher.
Limitations:
For in vitro research use only. Not for use in
diagnostics or in humans.
Warranty:
No warranties, expressed or implied, are made
regarding the use of this product. KAMIYA
BIOMEDICAL COMPANY is not liable for any
damage, personal injury, or economic loss
caused by this product.