RET/CEN10p FISH Probe
产品名称: RET/CEN10p FISH Probe
英文名称: RET/CEN10p FISH Probe
产品编号: FG0078
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique. (Technology)
- Storage Instruction:
- Store at 4°C in the dark.
- Quality Control Testing:
- Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
- Supplied Product:
- DAPI Counterstain (1500 ng/mL ) 250 uL
- Note:
- Hybridization position of the probes on the chromosome:
-
- Probe 1:
Size:
Fluorophore:
Location: - RET
Approximately 200kb
Texas Red
10q11.2
- Probe 2:
Size:
Fluorophore:
Location: - CEN10p
Approximately 640kb
FITC
10p11.22
- Probe Gap:
- The gap between two probes is approximately 11,600 kb.
- Origin:
- Human
- Source:
- Genomic DNA
- Regulation Status:
- For research use only (RUO)
- Applications
- Fluorescent In Situ Hybridization (Cell)
- Protocol Download
- Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge this image
- Human lung, adenosquamous cell carcinoma (FFPE) stained with RET/CEN10p FISH Probe. Human lung, adenosquamous cell carcinoma showed no RET gene amplification.
- Protocol Download
- Application Image
- Fluorescent In Situ Hybridization (Cell)
- Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- Entrez GeneID:
- 5979
- Gene Name:
- RET
- Gene Alias:
- CDHF12,HSCR1,MEN2A,MEN2B,MTC1,PTC,RET-ELE1,RET51
- Gene Description:
- ret proto-oncogene
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq
- Other Designations:
- RET transforming sequence,cadherin family member 12,hydroxyaryl-protein kinase,oncogene RET,receptor tyrosine kinase,ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
- Gene Pathway
- Related Disease
- Adenocarcinoma
- Adenocarcinoma, Follicular
- Adenocarcinoma, Papillary
- Adenoma
- Adrenal Gland Neoplasms
- Alzheimer Disease
- Atherosclerosis
- Atherosclerosis
- Carcinoma
- Carcinoma, Medullary
- Carcinoma, Papillary
- Carcinoma, Papillary, Follicular
- Cleft Lip
- Cleft Palate
- Digestive System Abnormalities
- Disease Progression
- Down Syndrome
- Endocrine Gland Neoplasms
- Esophageal Neoplasms