DYRK1A/CEN21q FISH Probe
产品名称： DYRK1A/CEN21q FISH Probe
英文名称： DYRK1A/CEN21q FISH Probe
产品编号： FG0015
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique. (Technology)
- Storage Instruction:
- Store at 4°C in the dark.
- Quality Control Testing:
- Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
- Supplied Product:
- DAPI Counterstain (1500 ng/mL ) 250 uL
- Note:
Hybridization position of the probes on the chromosome.-
- Probe 1:
Size:
Fluorophore:
Location: - DYRK1A
Approximately 570kb
Texas Red
21q22.13
- Probe 2:
Size:
Fluorophore:
Location: - CEN21q
Approximately 520kb
FITC
21q11.2
- Probe Gap:
- The gap between two probes is approximately 14,000 kb.
- Origin:
- Human
- Source:
- Genomic DNA
- Regulation Status:
- For research use only (RUO)
- Applications
- Fluorescent In Situ Hybridization (Cell)
- Protocol Download
- Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
enlarge this image- Human hepatocellular carcinoma (FFPE) stained with DYRK1A/CEN21q FISH Probe. Human hepatocellular carcinoma showed no DYRK1A gene amplification.
- Protocol Download
- Application Image
- Fluorescent In Situ Hybridization (Cell)
- Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- Entrez GeneID:
- 1859
- Gene Name:
- DYRK1A
- Gene Alias:
- DYRK,DYRK1,HP86,MNB,MNBH
- Gene Description:
- dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
- Omim ID:
- 600855
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq
- Other Designations:
- MNB/DYRK protein kinase,OTTHUMP00000109090,dual specificity YAK1-related kinase,minibrain homolog,mnb protein kinase homolog hp86,protein kinase minibrain homolog,serine/threonine kinase MNB,serine/threonine-specific protein kinase
- Related Disease