FITC标记的钙调磷酸酶B相关蛋白2抗体
产品名称： FITC标记的钙调磷酸酶B相关蛋白2抗体
英文名称： Anti-Chp2/FITC
产品编号： HZ-13923R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Chp2/FITC Conjugated antibody
FITC标记的钙调磷酸酶B相关蛋白2抗体
| 英文名称 | Anti-Chp2/FITC |
| 中文名称 | FITC标记的钙调磷酸酶B相关蛋白2抗体 |
| 别 名 | Calcineurin B homologous protein 2; HCA520; CHP2_HUMAN; Hepatocellular carcinoma associated antigen 520. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 结合蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 22kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Chp2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Chp2 binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. It is expressed in malignantly transformed cells but not detected in normal tissues. Function: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus. Subunit: Interacts with PPP3CA. Interacts with SLC9A1/NHE1; the interaction occurs in a calcium-dependent manner. Subcellular Location: Nucleus. Cytoplasm. Cell membrane. Note=Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane (By similarity). Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm. Tissue Specificity: Expressed in malignantly transformed cells butvnot detected in normal tissues. Similarity: Belongs to the calcineurin regulatory subunit family. CHP subfamily. Contains 4 EF-hand domains. Database links: Entrez Gene: 63928 Human Entrez Gene: 308965 Rat SwissProt: O43745 Human SwissProt: Q9D869 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
Chp2以与血清无关的方式结合并激活SLC9A1/NHE1，从而增加pH并保护细胞免受血清剥夺诱导的死亡。它在恶性转化细胞中表达，但在正常组织中未检测到。