TXNRD2 Pre-design Chimera RNAi
产品名称： TXNRD2 Pre-design Chimera RNAi
英文名称： TXNRD2 Pre-design Chimera RNAi
产品编号： H00010587-R02
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 邮编 : 11493
- 所在区域 : 台湾
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Homo sapiens thioredoxin reductase 2 (TXNRD2), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_145747
- Target Region:
- Coding sequence
- Note:
- Position of the Chimera RNAi.
The related RNAi products listed below were designed from different accesion number but sharing the same RNAi sequence. -
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 10587
- Gene Name:
- TXNRD2
- Gene Alias:
- SELZ,TR,TR-BETA,TR3,TRXR2
- Gene Description:
- thioredoxin reductase 2
- Omim ID:
- 606448
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Thioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. TR is a member of a family of pyridine nucleotide-disulfide oxidoreductases and is a key enzyme in the regulation of the intracellular redox environment. Three thioredoxin reductase genes have been found that encode selenocysteine containing proteins. This gene partially overlaps the COMT gene on chromosome 22. [provided by RefSeq
- Other Designations:
- OTTHUMP00000195708,selenoprotein Z,thioredoxin reductase 3,thioredoxin reductase beta
- Gene Pathway
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Arsenic Poisoning
- Breast cancer
- Breast Neoplasms
- Carcinoma, Ductal, Breast
- Carcinoma, Lobular
- Cardiovascular Diseases
- Cognition
- Colorectal Neoplasms
- Diabetes Mellitus, Type 2
- DNA Damage
- Drug Toxicity
- Edema
- Genetic Predisposition to Disease
- Hypercholesterolemia
- Kidney Failure, Chronic
- Osteoarthritis
- Stomach Neoplasms