Human Growth Factors & Cytokines
Recombinant Human Follistatin





 





		Synonyms :
FS, activins-binding protein



		Description :
Follistatin is a secreted protein that binds to ligands of the TGF-β family and regulates their activity by inhibiting their access to signaling receptors.  It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone).  In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-β ligands including BMP-2,-4,-6,-7, Myostatin, GDF-11, and TGF-β1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues.  Recombinant human Follistatin is a 31.5 kDa protein containing 288 amino acids.  Its primary structure contains three cysteine-rich domains (called FS domains), each followed by a protease-inhibitory kazal domain.



		Catalog #:
120-13



		Source :
E.coli



		Purity :
Greater than 95% by SDS-PAGE gel and HPLC analyses.



		Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).



		Biological Activity :
Determined by its ability to neutralize Activin A inhibitory effect of murine MPC-11 cells.  The expected ED50 is 0.1-0.4 μg/ml in the presence of 7.5 ng/ml Activin A.


Selected References :
Selected List of References Citing This PeproTech Product



                AA Sequence :
GNCWLRQAKN GRCQVLYKTE LSKEECCSTG RLSTSWTEED VNDNTLFKWM IFNGGAPNCI PCKETCENVD CGPGKKCRMN KKNKPRCVCA PDCSNITWKG PVCGLDGKTY RNECALLKAR CKEQPELEVQ YQGRCKKTCR DVFCPGSSTC VVDQTNNAYC VTCNRICPEP ASSEQYLCGN DGVTYSSACH LRKATCLLGR SIGLAYEGKC IKAKSCEDIQ CTGGKKCLWD FKVGRGRCSL CDELCPDSKS DEPVCASDNA TYASECAMKE AACSSGVLLE VKHSGSCN 



		PubMed Link :
Follistatin


Country of Origin :
USA
















        Size A
5μg
$80 
 


 



        Size B
20μg
$195 
 


 



        Size C
1mg
$5200 
 


 















Special 
                    Sizes: 
 Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.





Usage:
For Research Use Only.  Not for use in diagnostic or therapeutic procedures.